# BRCA1 DNA repair associated

> mammalian protein found in Homo sapiens

**Wikidata**: [Q17487737](https://www.wikidata.org/wiki/Q17487737)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/BRCA1)  
**Source**: https://4ort.xyz/entity/brca1-dna-repair-associated


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P38398)
3. Q20641742
4. [Roles of BRCA1 in centrosome duplication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
6. [BRCA1 participates in DNA decatenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
7. [Identification of a RING protein that can interact in vivo with the BRCA1 gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
8. [EXD2 promotes homologous recombination by facilitating DNA end resection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
9. [BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
10. [Highlight: BRCA1 and BRCA2 proteins in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
11. [BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
12. [The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
13. [CCDC98 targets BRCA1 to DNA damage sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
14. [The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
15. [Identification of DBC1 as a transcriptional repressor for BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
16. [BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
17. [VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
18. [BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
19. [MERIT40 facilitates BRCA1 localization and DNA damage repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
20. [PALB2 is an integral component of the BRCA complex required for homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
21. [ATM activation by ionizing radiation requires BRCA1-associated BAAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
22. [SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
23. [KIAA0101 Interacts with BRCA1 and Regulates Centrosome Number](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
24. [CDK targets Sae2 to control DNA-end resection and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
25. [The BRCT Domain Is a Phospho-Protein Binding Domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
26. [BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
27. [Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
28. [Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
29. [BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
30. [Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
31. [Multifunctional transcription factor TFII-I is an activator of BRCA1 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
32. [The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
33. [The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
34. [Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
35. [Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
36. [RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
37. [Identification of a Novel Cytoplasmic Protein That Specifically Binds to Nuclear Localization Signal Motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
38. [Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
39. [Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
40. [FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
41. [BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
42. [E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
43. [Characterization of a carboxy-terminal BRCA1 interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
44. [Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
45. [ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
46. [BRCA1 interacts with FHL2 and enhances FHL2 transactivation function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
47. [TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
48. [MDC1 is a mediator of the mammalian DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
49. [ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)
50. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398)