# Braf transforming gene

> mammalian protein found in Mus musculus

**Wikidata**: [Q21493994](https://www.wikidata.org/wiki/Q21493994)  
**Source**: https://4ort.xyz/entity/braf-transforming-gene


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P28028)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
5. [Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
6. [Ring Finger Protein 149 Is an E3 Ubiquitin Ligase Active on Wild-type v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
7. [Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
8. [ERK and PDE4 cooperate to induce RAF isoform switching in melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
9. [Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
10. [IQGAP1 modulates activation of B-Raf](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
13. [Cortical migration defects in mice expressing A-RAF from the B-RAF locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
14. [Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028)
15. [Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
16. [Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028)
17. [Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
18. [B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
19. [Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
20. [B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
21. [Endothelial apoptosis in Braf-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
22. [B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
23. [A critical function for B-Raf at multiple stages of myelopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
24. [B-Raf and C-Raf are required for melanocyte stem cell self-maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
25. [Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
26. [Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
27. [STAT3 negatively regulates thyroid tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
28. [B-Raf-mediated signaling pathway regulates T cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
29. [The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28028)
30. [B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P28028&geneProductId=UniProtKB:P28028)
32. ensembl Release 106