# bone morphogenetic protein 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q700001](https://www.wikidata.org/wiki/Q700001)  
**Source**: https://4ort.xyz/entity/bone-morphogenetic-protein-4-q700001


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12644)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
6. [Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
7. [Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
9. [A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
10. [The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
11. [Agrin binds BMP2, BMP4 and TGFbeta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
12. [Targeting of bone morphogenetic protein growth factor complexes to fibrillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
13. [DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
14. [WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
15. [The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
16. [Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
17. [Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
18. [Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
19. [A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
20. [Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
21. [Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
22. [Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
23. [BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
24. [Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
25. [BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
26. [Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
27. [Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
28. [Ureteric branching morphogenesis in BMP4 heterozygous mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
29. [BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
30. [Involvement of FGF and BMP family proteins and VEGF in early human kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
31. [Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
32. [BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
33. [Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
34. [Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
35. [Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
36. [Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
37. [Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
38. [Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
39. [SIX2 and BMP4 mutations associate with anomalous kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
40. [The surface ectoderm is essential for nephric duct formation in intermediate mesoderm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
41. [BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
42. [Regulation of bone morphogenetic protein signalling in human pulmonary vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
43. [Novel regulators of bone formation: molecular clones and activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
44. [Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
45. [Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
46. [GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644)
47. [Regulation of bone morphogenetic protein signalling in human pulmonary vascular development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
48. [Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
49. [Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)
50. [BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644)