# bone morphogenetic protein 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q699997](https://www.wikidata.org/wiki/Q699997)  
**Source**: https://4ort.xyz/entity/bone-morphogenetic-protein-2-q699997


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12643)
3. Q20641742
4. [Recombinant human bone morphogenetic protein induces bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
7. [Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
8. [Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
9. [Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
10. [A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)
11. [Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
12. [The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
13. [Agrin binds BMP2, BMP4 and TGFbeta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
14. [Targeting of bone morphogenetic protein growth factor complexes to fibrillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
15. [DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
16. [Molecular recognition of BMP-2 and BMP receptor IA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
17. [Structure of the ternary signaling complex of a TGF-beta superfamily member](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
18. [WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
19. [Crystal structure of the BMP-2-BRIA ectodomain complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
20. [The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
21. [Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
22. [Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
23. [Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
24. [The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
25. [A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)
28. [Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
29. [Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)
30. [MADR1, a MAD-related protein that functions in BMP2 signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
31. [Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
32. [Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
33. [Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
34. [BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
35. [Regulation of BMP7 expression during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
36. [Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
37. [Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
38. [Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
39. [BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
40. [Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
41. [Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
42. [Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
43. [DRAGON, a bone morphogenetic protein co-receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
44. [Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)
45. [Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
46. [Gremlin enhances the determined path to cardiomyogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
47. [Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
48. [Novel regulators of bone formation: molecular clones and activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
49. [BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643)
50. [MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643)