# BLM RecQ like helicase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q885306](https://www.wikidata.org/wiki/Q885306)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Bloom_syndrome_protein)  
**Source**: https://4ort.xyz/entity/blm-recq-like-helicase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P54132)
3. Q20641742
4. [Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
6. [Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
7. [Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
8. [Characterization and mutational analysis of the RecQ core of the bloom syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
9. [BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
10. [Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
11. [The Bloom's Syndrome Gene Product Is a 3′-5′ DNA Helicase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
12. [Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
13. [The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
14. [Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
15. [The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
16. [Structure and function of the regulatory HRDC domain from human Bloom syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
17. [Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
18. [Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
19. [Regulation and localization of the Bloom syndrome protein in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
20. [Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
21. [Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
22. [Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
23. [hSSB1 associates with and promotes stability of the BLM helicase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
24. [MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
25. [Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
26. [Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
27. [Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
28. [Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
29. [Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
30. [Stimulation of flap endonuclease-1 by the Bloom's syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
31. [Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
32. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
33. [hPrimpol1/CCDC111 is a human DNA primase‐polymerase required for the maintenance of genome integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
34. [Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
35. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
36. [BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
37. [POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
38. [Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
39. [The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
40. [Characterization and mutational analysis of the RecQ core of the bloom syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
41. [Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
42. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
43. [Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
44. [A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
45. [Nuclear structure in normal and Bloom syndrome cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
46. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
47. [The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
48. [BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54132&geneProductId=UniProtKB:P54132)
49. [BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)
50. [The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54132)