Bifunctional K:H/Na:H antiporter NHX1 YDR456W
type: Thing
description: fungal protein found in Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Monovalent cation:proton antiporter-1
additional property: PropertyValue
  property ID: P637
  value: NP_010744
additional property: PropertyValue
  property ID: P680
  value: solute:proton antiporter activity
additional property: PropertyValue
  property ID: P680
  value: sodium:proton antiporter activity
additional property: PropertyValue
  property ID: P680
  value: potassium:proton antiporter activity
additional property: PropertyValue
  property ID: P681
  value: late endosome
additional property: PropertyValue
  property ID: P681
  value: late endosome membrane
additional property: PropertyValue
  property ID: P681
  value: early endosome
additional property: PropertyValue
  property ID: P682
  value: ion transport
additional property: PropertyValue
  property ID: P682
  value: potassium ion transport
additional property: PropertyValue
  property ID: P682
  value: cation transport
additional property: PropertyValue
  property ID: P702
  value: NHX1
additional property: PropertyValue
  property ID: P703
  value: Saccharomyces cerevisiae S288c
additional property: PropertyValue
  property ID: P705
  value: YDR456W
additional property: PropertyValue
  property ID: P3406
  value: S000002864
additional property: PropertyValue
  property ID: P7260
  value: 2.A.36.1.12
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 23
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q04121
    source count: 1
    confidence: 0.2
  P361:
    value: Q25323876
    source count: 1
    confidence: 0.2
    value label: Monovalent cation:proton antiporter-1
  P637:
    value: NP_010744
    source count: 1
    confidence: 0.2
  P680:
    value: Q21123410
    source count: 1
    confidence: 0.2
    value label: solute:proton antiporter activity
  P680:
    value: Q21107997
    source count: 3
    confidence: 0.6
    value label: sodium:proton antiporter activity
  P680:
    value: Q21123423
    source count: 1
    confidence: 0.2
    value label: potassium:proton antiporter activity
  P680:
    value: Q14881097
    source count: 1
    confidence: 0.2
    value label: antiporter activity
  P680:
    value: Q21107997
    source count: 4
    confidence: 0.8
    value label: sodium:proton antiporter activity
  P681:
    value: Q14860539
    source count: 3
    confidence: 0.6
    value label: late endosome
  P681:
    value: Q14904869
    source count: 1
    confidence: 0.2
    value label: late endosome membrane
  P681:
    value: Q14860538
    source count: 1
    confidence: 0.2
    value label: early endosome
  P681:
    value: Q824237
    source count: 1
    confidence: 0.2
    value label: endosome
  P681:
    value: Q22327865
    source count: 1
    confidence: 0.2
    value label: fungal-type vacuole membrane
  P682:
    value: Q14859673
    source count: 1
    confidence: 0.2
    value label: ion transport
  P682:
    value: Q14860315
    source count: 1
    confidence: 0.2
    value label: potassium ion transport
  P682:
    value: Q14884611
    source count: 1
    confidence: 0.2
    value label: cation transport
  P682:
    value: Q14865157
    source count: 1
    confidence: 0.2
    value label: potassium ion transmembrane transport
  P682:
    value: Q14907460
    source count: 1
    confidence: 0.2
    value label: regulation of pH
  P702:
    value: Q27544366
    source count: 1
    confidence: 0.2
    value label: NHX1
  P703:
    value: Q27510868
    source count: 1
    confidence: 0.2
    value label: Saccharomyces cerevisiae S288c
  P705:
    value: YDR456W
    source count: 1
    confidence: 0.2
  P3406:
    value: S000002864
    source count: 1
    confidence: 0.2
  P7260:
    value: 2.A.36.1.12
    source count: 2
    confidence: 0.4
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-05-09
citations:
  source: The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking
  stated in qid: Q27936889
  retrieved: 2018-07-16
citations:
  source: Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na+/H+ exchangers
  stated in qid: Q27933440
  retrieved: 2018-07-16
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2018-07-16

source: Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na+/H+ exchangers
stated in qid: Q27933440
retrieved: 2019-05-09

source: The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking
stated in qid: Q27936889
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway
stated in qid: Q27932527
retrieved: 2018-07-16

source: Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis
stated in qid: Q27931691
retrieved: 2018-07-16

source: Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae
stated in qid: Q27930342
retrieved: 2018-07-16

source: The Na+/H+ exchanger Nhx1p regulates the initiation of Saccharomyces cerevisiae vacuole fusion
stated in qid: Q27934178
retrieved: 2018-07-16

source: Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway
stated in qid: Q27932527
retrieved: 2019-05-09

source: The Na+/H+ exchanger Nhx1p regulates the initiation of Saccharomyces cerevisiae vacuole fusion
stated in qid: Q27934178
retrieved: 2019-05-09

source: Vacuolar cation/H+ antiporters of Saccharomyces cerevisiae
stated in qid: Q27930342
retrieved: 2019-05-09

source: Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis
stated in qid: Q27931691
retrieved: 2019-05-09

source: One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
stated in qid: Q35940377
retrieved: 2019-05-09

source: Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae
stated in qid: Q34794191
retrieved: 2019-01-14

source: The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock
stated in qid: Q27936649
retrieved: 2019-05-09

source: The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock
stated in qid: Q27936649
retrieved: 2018-07-16

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q27551424
domain: protein
level: standard
html url: https://4ort.xyz/entity/bifunctional-k-h-na-h-antiporter-nhx1-ydr456w
markdown url: https://4ort.xyz/entity/bifunctional-k-h-na-h-antiporter-nhx1-ydr456w.md
facts url summary: https://4ort.xyz/entity/bifunctional-k-h-na-h-antiporter-nhx1-ydr456w/facts.json
facts url standard: https://4ort.xyz/entity/bifunctional-k-h-na-h-antiporter-nhx1-ydr456w/facts.json
facts url full: https://4ort.xyz/entity/bifunctional-k-h-na-h-antiporter-nhx1-ydr456w/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-08T15:34:02.581729Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:48:18.333862+00:00Z