# BH3 interacting domain death agonist

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4835575](https://www.wikidata.org/wiki/Q4835575)  
**Source**: https://4ort.xyz/entity/bh3-interacting-domain-death-agonist


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P55957)
3. Q20641742
4. [BID: a novel BH3 domain-only death agonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
5. [PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
6. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
7. [Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
8. [Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
9. [The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
10. [BID-induced structural changes in BAK promote apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
11. [Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
12. [Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
13. [Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
14. [Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
16. [Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
17. [Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
18. [BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
19. [Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
20. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
21. [Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
22. [Caveolin-1 mediates Fas–BID signaling in hyperoxia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
23. [The DNA-binding domain mediates both nuclear and cytosolic functions of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
24. [A stapled BID BH3 helix directly binds and activates BAX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
25. [Heterodimerization of BAK and MCL-1 activated by detergent micelles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
28. [Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
29. [BID: a novel BH3 domain-only death agonist](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
30. [PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
31. [Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
33. [Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
34. [BH3 domains other than Bim and Bid can directly activate Bax/Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
35. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
36. [Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
37. [Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
38. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
39. [MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
40. [BH3 domains other than Bim and Bid can directly activate Bax/Bak](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
41. [Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55957&geneProductId=UniProtKB:P55957)
42. [Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
43. [MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
44. [Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55957)
45. Ensembl Release 99