# Beta-transducin repeat containing E3 ubiquitin protein ligase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116841](https://www.wikidata.org/wiki/Q21116841)  
**Source**: https://4ort.xyz/entity/beta-transducin-repeat-containing-e3-ubiquitin-protein-ligase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y297)
3. Q20641742
4. [Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
5. [Prophase Destruction of Emi1 by the SCFβTrCP/Slimb Ubiquitin Ligase Activates the Anaphase Promoting Complex to Allow Progression beyond Prometaphase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
6. [Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
7. [C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
8. [Identification of the receptor component of the IκBα–ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
9. [HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
10. [Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
11. [SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Proteinm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
12. [Evidence for the direct involvement of βTrCP in Gli3 protein processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
13. [SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
14. [The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
15. [Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
16. [Mutant huntingtin‐impaired degradation of β‐catenin causes neurotoxicity in Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
17. [M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF β-TrCP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
18. [MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
19. [Control of chromosome stability by the β-TrCP–REST–Mad2 axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
20. [Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
21. [TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
22. [USP10 inhibits genotoxic NF‐κB activation by MCPIP1‐facilitated deubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
23. [Structure of a β-TrCP1-Skp1-β-Catenin Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
24. [Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
25. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
26. [Regulation of the Discs Large Tumor Suppressor by a Phosphorylation-dependent Interaction with the β-TrCP Ubiquitin Ligase Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
27. [Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
28. [CSN controls NF‐κB by deubiquitinylation of IκBα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
29. [The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
30. [Defining the Human Deubiquitinating Enzyme Interaction Landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
31. [ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
32. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
33. [Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
34. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
35. [A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
36. [Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
37. [LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
38. [ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
39. [14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
40. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
41. [Array MAPPIT: High-Throughput Interactome Analysis in Mammalian Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
42. [Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
43. [The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c‐Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
44. [MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
45. [SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
46. [Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
47. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
48. [TIP120A Associates with Cullins and Modulates Ubiquitin Ligase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
49. [The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)
50. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297)