# Beta-secretase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q737488](https://www.wikidata.org/wiki/Q737488)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Beta-secretase_1)  
**Source**: https://4ort.xyz/entity/beta-secretase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P56817)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
6. [Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
8. [Purification and cloning of amyloid precursor protein beta-secretase from human brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
9. [Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
10. [Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
11. [GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
12. [Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
13. [β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
14. [Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
15. [Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
16. [BIN1 regulates BACE1 intracellular trafficking and amyloid-β production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
17. [Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
18. [Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
19. [Inhibition of beta A4 production by specific modulation of beta-secretase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
20. [Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
22. [Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
23. [Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
24. [Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
25. [Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
26. [The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
27. [Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
28. [BACE is degraded via the lysosomal pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
29. [BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
30. [The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
31. [SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
32. [Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
33. [The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
34. [BACE (beta-secretase) modulates the processing of APLP2 in vivo](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
35. [The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
36. [A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P56817)
37. [The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
38. [A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
39. [MiR-124 acts as a target for Alzheimer's disease by regulating BACE1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
40. [BACE (beta-secretase) modulates the processing of APLP2 in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817)
41. Ensembl Release 99
42. Identifiers.org
43. Transporter Classification database