# Beta-secretase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561740](https://www.wikidata.org/wiki/Q28561740)  
**Source**: https://4ort.xyz/entity/beta-secretase-1-q28561740


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P56819)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
6. [Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
7. [ADAM10 and BACE1 are localized to synaptic vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
8. [Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
9. [Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
10. [Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
11. [miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
12. [BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
13. [Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
14. [miR-124 Regulates the Expression of BACE1 in the Hippocampus Under Chronic Cerebral Hypoperfusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56819)
15. ensembl Release 106