# Beclin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21097409](https://www.wikidata.org/wiki/Q21097409)  
**Source**: https://4ort.xyz/entity/beclin-1-q21097409


## References

1. UniProt
2. Q20641742
3. [Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
4. [Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
5. [TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
6. [Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
7. [Placental autophagy regulation by the BOK-MCL1 rheostat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
8. [Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
9. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
10. [Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
11. [A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
12. [Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
13. [The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
14. [Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
15. [PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
16. [NRBF2 regulates macroautophagy as a component of Vps34 Complex I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
17. [Identification of a candidate therapeutic autophagy-inducing peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
18. [A kinase-independent role for EGF receptor in autophagy initiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
19. [Endogenous HMGB1 regulates autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
20. [Polyglutamine tracts regulate beclin 1-dependent autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
21. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
22. [Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
23. [Targeting  -Herpesvirus 68 Bcl-2-mediated Down-regulation of Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
24. [The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
25. [Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
26. [Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
27. [Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
28. [Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
29. [MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
30. [The VMP1-Beclin 1 interaction regulates autophagy induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
31. [Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
32. [Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
33. [WASH inhibits autophagy through suppression of Beclin 1 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
34. [AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
35. [Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
36. [Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
37. [An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
38. [Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
39. [Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
40. [RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
41. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
42. [Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
43. [The IKK complex contributes to the induction of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
44. [EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
45. [UV irradiation resistance‐associated gene suppresses apoptosis by interfering with BAX activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
46. [DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
47. [Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
48. [Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
49. [Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)
50. [PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457)