# BCR activator of RhoGEF and GTPase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q903924](https://www.wikidata.org/wiki/Q903924)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/BCR_(gene))  
**Source**: https://4ort.xyz/entity/bcr-activator-of-rhogef-and-gtpase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11274)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
5. [The BCR gene encodes a novel serine/threonine kinase activity within a single exon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
6. [Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
7. [Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
8. [The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
9. [Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
10. [Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
11. [Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
12. [Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
13. [Bcr phosphorylated on tyrosine 177 binds Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
14. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
15. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
16. [The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
17. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274)
19. [Bcr encodes a GTPase-activating protein for p21rac](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274)
20. [Bcr encodes a GTPase-activating protein for p21rac](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
21. [The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
22. [Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
23. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274)
24. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11274&geneProductId=UniProtKB:P11274)
25. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
26. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
27. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11274)
28. Ensembl Release 99
29. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
30. UMLS 2023
31. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)