# BCL2 like 11

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100273](https://www.wikidata.org/wiki/Q21100273)  
**Source**: https://4ort.xyz/entity/bcl2-like-11


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43521)
3. Q20641742
4. [Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
5. [Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
6. [Structure homology and interaction redundancy for discovering virus-host protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
7. [RACK1 and CIS mediate the degradation of BimEL in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
8. [BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
9. [Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
10. [Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
11. [Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
12. [BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
13. [High-throughput methods to detect dimerization of Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
14. [Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
15. [Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
16. [The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
17. [Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
18. [Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
19. [Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
20. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
21. [The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
22. [BAX activation is initiated at a novel interaction site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
23. [Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
24. [Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
25. [Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
26. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
27. [The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
28. [Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
29. [BAX-induced apoptosis can be initiated through a conformational selection mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
30. [ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43521&geneProductId=UniProtKB:O43521)
32. [Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43521&geneProductId=UniProtKB:O43521)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
35. [BH3 domains other than Bim and Bid can directly activate Bax/Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
36. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
37. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
38. [Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
39. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43521&geneProductId=UniProtKB:O43521)
40. [Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
41. [A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
42. [BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
43. [Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43521)
44. Ensembl Release 99
45. Transporter Classification database