# BCL2-like 11 (apoptosis facilitator)

> mammalian protein found in Mus musculus

**Wikidata**: [Q21497037](https://www.wikidata.org/wiki/Q21497037)  
**Source**: https://4ort.xyz/entity/bcl2-like-11-apoptosis-facilitator-


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O54918)
3. Q20641742
4. [Identification of a Novel Bcl-2-interacting Mediator of Cell Death (Bim) E3 Ligase, Tripartite Motif-containing Protein 2 (TRIM2), and Its Role in Rapid Ischemic Tolerance-induced Neuroprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
5. [The deubiquitinase Usp27x stabilizes the BH3‐only protein Bim and enhances apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
6. [Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
7. [Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
8. [Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
9. [Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
10. [Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
11. [The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
12. [Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
13. [Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
15. [The NF-κB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
16. [Temporal Profiles of the Subcellular Localization of Bim, a BH3-Only Protein, during Middle Cerebral Artery Occlusion in Mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
18. [The NF-κB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
20. [Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
21. [Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
22. [Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
23. [Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
24. [Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
25. [Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
26. [Polycystic kidney disease prevented by transgenic RNA interference](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
27. [BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
28. [BIM Regulates Apoptosis during Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
29. [Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
30. [Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
31. [Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
32. [Bim regulates BCR‐induced entry of B cells into the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
33. [Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54918)
34. [BIM Regulates Apoptosis during Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
35. [Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
36. [Polycystic kidney disease prevented by transgenic RNA interference](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54918&geneProductId=UniProtKB:O54918)
37. ensembl Release 106