# BCL2 like 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173156](https://www.wikidata.org/wiki/Q21173156)  
**Source**: https://4ort.xyz/entity/bcl2-like-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07817)
4. Q20641742
5. [Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
6. [PUMA induces the rapid apoptosis of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
7. [Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
8. [RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
9. [Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
10. [Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
11. [FAST is a BCL-X(L)-associated mitochondrial protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
12. [Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
13. [Bcl-G, a novel pro-apoptotic member of the Bcl-2 family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
14. [The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
15. [The Association of Aiolos Transcription Factor and Bcl-xL Is Involved in the Control of Apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
16. [A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
17. [c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
18. [p53 has a direct apoptogenic role at the mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
19. [Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
20. [Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
21. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
22. [Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
23. [Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
24. [Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
25. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
26. [The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
27. [Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
28. [The DNA-binding domain mediates both nuclear and cytosolic functions of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
29. [High-throughput methods to detect dimerization of Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
30. [PUMA couples the nuclear and cytoplasmic proapoptotic function of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
31. [Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
32. [Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
33. [Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
34. [Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
35. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
36. [HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
37. [Human Bop is a novel BH3-only member of the Bcl-2 protein family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
38. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
39. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
40. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
41. [Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
42. [The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
43. [Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
44. [Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
45. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
46. [Bcl-XL inhibits membrane permeabilization by competing with Bax.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
47. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
48. [Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
49. [Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)
50. [Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07817)