# BCL2-associated X protein

> mammalian protein found in Mus musculus

**Wikidata**: [Q14905404](https://www.wikidata.org/wiki/Q14905404)  
**Source**: https://4ort.xyz/entity/bcl2-associated-x-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07813)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
5. [Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
6. [Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
7. [BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
8. [Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
9. [hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
10. [Bcl-2 family interaction with the mitochondrial morphogenesis machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
11. [BID: a novel BH3 domain-only death agonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
12. [Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
13. [Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
14. [Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
15. [Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
16. [Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
17. [MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
19. [Bcl-XL and Bcl-2 repress a common pathway of cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
20. [Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
21. [Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
22. [BID: a novel BH3 domain-only death agonist](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
23. [Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
24. [hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
26. [Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
27. [Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
28. [Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
29. [Bcl-XL and Bcl-2 repress a common pathway of cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
30. [Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
31. [Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
32. [Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
33. [The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
34. [Spatial and temporal changes in Bax subcellular localization during anoikis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
35. [Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
36. [Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
37. [Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
38. [BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
39. [Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
40. [Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
41. [Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813)
42. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
43. [The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
44. [Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
45. [Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
46. [Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
47. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
48. [The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
49. [Caspases 3 and 7: key mediators of mitochondrial events of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)
50. [BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813)