# BCL2 associated X, apoptosis regulator

> mammalian protein found in Homo sapiens

**Wikidata**: [Q408476](https://www.wikidata.org/wiki/Q408476)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Apoptosis_regulator_BAX)  
**Source**: https://4ort.xyz/entity/bcl2-associated-x-apoptosis-regulator


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07812)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07812)
6. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07812)
7. [PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07812)
8. [Inhibition of Bax channel-forming activity by Bcl-2](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q07812)
9. [Humanin peptide suppresses apoptosis by interfering with Bax activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
10. [RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
11. [IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
12. [Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
13. [IAN family critically regulates survival and development of T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
14. [Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
15. [Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
16. [Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
17. [Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
18. [Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
19. [Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
20. [Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
21. [Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
22. [The DNA-binding domain mediates both nuclear and cytosolic functions of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
23. [BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
24. [Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
25. [Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
26. [PUMA couples the nuclear and cytoplasmic proapoptotic function of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
27. [Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
28. [Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
29. [Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
30. [Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
31. [ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
32. [Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
33. [Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
34. [Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
35. [Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
36. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
37. [Human Bop is a novel BH3-only member of the Bcl-2 protein family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
38. [BAX activation is initiated at a novel interaction site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
39. [Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
40. [The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
41. [The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
42. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
43. [Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
44. [Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
45. [Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
46. [An interconnected hierarchical model of cell death regulation by the BCL-2 family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
47. [UV irradiation resistance‐associated gene suppresses apoptosis by interfering with BAX activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
48. [The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
49. [Bcl-XL inhibits membrane permeabilization by competing with Bax.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)
50. [Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812)