# BCL2 associated agonist of cell death

> mammalian protein found in Homo sapiens

**Wikidata**: [Q812784](https://www.wikidata.org/wiki/Q812784)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Bcl-2-associated_death_promoter)  
**Source**: https://4ort.xyz/entity/bcl2-associated-agonist-of-cell-death


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92934)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
6. [Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
7. [BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
8. [Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
9. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
10. [PTH inactivates the AKT survival pathway in the colonic cell line Caco-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
11. [Structure homology and interaction redundancy for discovering virus-host protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
12. [The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
13. [Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
14. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
15. [Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
16. [BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
17. [Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
18. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
19. [Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
20. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
21. [Protection from Rapamycin-Induced Apoptosis by Insulin-Like Growth Factor-I Is Partially Dependent on Protein Kinase C Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
22. [The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
23. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
24. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
25. [Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
26. [Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
27. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
28. [Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
29. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
30. [The BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
31. [Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
32. [Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
33. [Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
35. [Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
36. [Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
37. [Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
38. [Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
39. [Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
40. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
41. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
42. [Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
43. [A pathway sensor for genome-wide screens of intracellular proteolytic cleavage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
44. [A pathway sensor for genome-wide screens of intracellular proteolytic cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
45. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
46. [Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
47. [Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92934&geneProductId=UniProtKB:Q92934)
48. [Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
49. [Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92934)
50. Ensembl Release 99