# BCL2-antagonist/killer 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21497080](https://www.wikidata.org/wiki/Q21497080)  
**Source**: https://4ort.xyz/entity/bcl2-antagonist-killer-1-q21497080


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O08734)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
5. [BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
6. [Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
7. [IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
8. [VDAC2 inhibits BAK activation and mitochondrial apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
9. [Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
10. [Structural plasticity underpins promiscuous binding of the prosurvival protein A1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
11. [Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
12. [BH3 domains other than Bim and Bid can directly activate Bax/Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
13. [tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
16. [Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
17. [Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
18. [Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
19. [Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
20. [Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
21. [Role of Bax and Bak in mitochondrial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
22. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
23. [Role of Bax and Bak in mitochondrial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
24. [Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
25. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
26. [Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
27. [The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
28. [Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
29. [The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
30. [Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
31. [Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
32. [Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
33. [Persistent fetal ocular vasculature in mice deficient in bax and bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
34. [Proapoptotic BAX and BAK control multiple initiator caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
35. [Bax and Bak independently promote cytochrome C release from mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
36. [Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
37. [Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
38. [Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
39. [Growth factor regulation of autophagy and cell survival in the absence of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734)
40. [Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)
41. [Growth factor regulation of autophagy and cell survival in the absence of apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734)