# Bcl-2-binding component 3

> human protein (annotated by UniProtKB/Swiss-Prot Q9BXH1)

**Wikidata**: [Q22683593](https://www.wikidata.org/wiki/Q22683593)  
**Source**: https://4ort.xyz/entity/bcl-2-binding-component-3-q22683593


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9BXH1)
3. [PUMA induces the rapid apoptosis of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
4. [PUMA, a novel proapoptotic gene, is induced by p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
5. [DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
6. [Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
7. [Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
8. [Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
9. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
10. [Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
11. [The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
12. [PUMA couples the nuclear and cytoplasmic proapoptotic function of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
13. [PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
15. [Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
16. [BH3 domains other than Bim and Bid can directly activate Bax/Bak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
17. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
18. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
19. [Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
20. [PUMA, a novel proapoptotic gene, is induced by p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXH1&geneProductId=UniProtKB:Q9BXH1)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXH1&geneProductId=UniProtKB:Q9BXH1)
22. [Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BXH1&geneProductId=UniProtKB:Q9BXH1)
23. [Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)
24. [Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BXH1)