Basic helix-loop-helix family member e41
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Helix-loop-helix DNA-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Myc-type, basic helix-loop-helix (bHLH) domain, protein family
additional property: PropertyValue
  property ID: P361
  value: Orange domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Orange domain
additional property: PropertyValue
  property ID: P527
  value: Myc-type, basic helix-loop-helix (bHLH) domain
additional property: PropertyValue
  property ID: P637
  value: NP_110389
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: protein dimerization activity
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: cell differentiation
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: rhythmic process
additional property: PropertyValue
  property ID: P702
  value: BHLHE41
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000242728
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 16
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 16
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9C0J9
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797740
    source count: 1
    confidence: 0.2
    value label: Helix-loop-helix DNA-binding domain superfamily
  P361:
    value: Q83146427
    source count: 1
    confidence: 0.2
    value label: Myc-type, basic helix-loop-helix (bHLH) domain, protein family
  P361:
    value: Q83166175
    source count: 1
    confidence: 0.2
    value label: Orange domain, protein family
  P527:
    value: Q24787055
    source count: 1
    confidence: 0.2
    value label: Orange domain
  P527:
    value: Q24777807
    source count: 1
    confidence: 0.2
    value label: Myc-type, basic helix-loop-helix (bHLH) domain
  P637:
    value: NP_110389
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q14861864
    source count: 1
    confidence: 0.2
    value label: protein dimerization activity
  P680:
    value: Q14762996
    source count: 2
    confidence: 0.4
    value label: protein homodimerization activity
  P680:
    value: Q14911856
    source count: 2
    confidence: 0.4
    value label: MRF binding
  P680:
    value: Q14864664
    source count: 2
    confidence: 0.4
    value label: transcription corepressor activity
  P681:
    value: Q40260
    source count: 1
    confidence: 0.2
    value label: nucleus
  P681:
    value: Q40260
    source count: 2
    confidence: 0.4
    value label: nucleus
  P682:
    value: Q210861
    source count: 1
    confidence: 0.2
    value label: cell differentiation
  P682:
    value: Q14633883
    source count: 1
    confidence: 0.2
    value label: regulation of transcription, DNA-templated
  P682:
    value: Q14864472
    source count: 1
    confidence: 0.2
    value label: rhythmic process
  P682:
    value: Q14904366
    source count: 2
    confidence: 0.4
    value label: negative regulation of transcription by competitive promoter binding
  P682:
    value: Q14633878
    source count: 3
    confidence: 0.6
    value label: negative regulation of transcription by RNA polymerase II
  P702:
    value: Q18046111
    source count: 1
    confidence: 0.2
    value label: BHLHE41
  P703:
    value: Q15978631
    source count: 1
    confidence: 0.2
    value label: Homo sapiens
  P705:
    value: ENSP00000242728
    source count: 1
    confidence: 0.2
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-05-09
citations:
  source: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
  stated in qid: Q24319119
  retrieved: 2019-05-09
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2018-03-27
citations:
  source: DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
  stated in qid: Q24296459
  retrieved: 2019-05-09

source: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
stated in qid: Q24301731
retrieved: 2019-05-09

source: SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.
stated in qid: Q34288454
retrieved: 2019-05-09

source: A census of human transcription factors: function, expression and evolution
stated in qid: Q29622841
retrieved: 2018-03-27

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: A census of human transcription factors: function, expression and evolution
stated in qid: Q29622841
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
stated in qid: Q24290766
retrieved: 2018-03-27

source: Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
stated in qid: Q24290766
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21115531
domain: protein
level: standard
html url: https://4ort.xyz/entity/basic-helix-loop-helix-family-member-e41
markdown url: https://4ort.xyz/entity/basic-helix-loop-helix-family-member-e41.md
facts url summary: https://4ort.xyz/entity/basic-helix-loop-helix-family-member-e41/facts.json
facts url standard: https://4ort.xyz/entity/basic-helix-loop-helix-family-member-e41/facts.json
facts url full: https://4ort.xyz/entity/basic-helix-loop-helix-family-member-e41/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T11:15:48.306782Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:42.669745+00:00Z