# B-Raf proto-oncogene, serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109218](https://www.wikidata.org/wiki/Q21109218)  
**Source**: https://4ort.xyz/entity/b-raf-proto-oncogene-serine-threonine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P15056)
4. Q20641742
5. [Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
7. [IQGAP1 modulates activation of B-Raf](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
8. [IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15056&geneProductId=UniProtKB:P15056)
10. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15056&geneProductId=UniProtKB:P15056)
11. [Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
12. [The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
13. [Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
14. [Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
15. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
16. [ERK and PDE4 cooperate to induce RAF isoform switching in melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
17. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
18. [FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
19. [Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
20. [Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
21. [Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
22. [RAF inhibitors that evade paradoxical MAPK pathway activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
23. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
24. [Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
25. [Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
26. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
27. [Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
28. [Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
29. [Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
30. [RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
31. [Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
32. [Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
33. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
34. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
35. [The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
36. [A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
37. [RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
38. [Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
39. [A dimerization-dependent mechanism drives RAF catalytic activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
40. [The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
41. [Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
42. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
43. [Stimulation of the Na(+)-coupled glucose transporter SGLT1 by B-RAF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
44. [Endothelial apoptosis in Braf-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
45. [Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
46. [Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15056)
47. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15056&geneProductId=UniProtKB:P15056)
48. Ensembl Release 99
49. UMLS 2023