# Axin 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981220](https://www.wikidata.org/wiki/Q21981220)  
**Source**: https://4ort.xyz/entity/axin-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O35625)
3. Q20641742
4. [A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
5. [Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
6. [Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
7. [Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
8. [Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
9. [Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
10. [Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
11. [SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
12. [N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
13. [The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
14. [Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
15. [Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
16. [Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
17. [Regulation of the Wnt signaling pathway by disabled-2 (Dab2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
18. [Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
19. [Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
20. [A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
21. [Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
22. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
23. [TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
24. [Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
25. [YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
26. [Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
27. [Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
29. [Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)
31. [Functional domains of axin. Importance of the C terminus as an oligomerization domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
32. [SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)
33. [Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)
34. [Functional domains of axin. Importance of the C terminus as an oligomerization domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)
35. [A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)
36. [LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
37. [Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
38. [A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
39. [Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
40. [Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
41. [Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
42. [The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
43. [Inhibition of adipogenesis by Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
44. [Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
45. [A role for Wnt signalling in self-renewal of haematopoietic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
46. [Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
47. [Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
48. [Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
49. [A case of neighboring loci with similar effects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625)
50. [A role for Wnt signalling in self-renewal of haematopoietic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625)