# Axin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109410](https://www.wikidata.org/wiki/Q21109410)  
**Source**: https://4ort.xyz/entity/axin-1-q21109410


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15169)
3. Q20641742
4. [Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
6. [Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
7. [Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15169&geneProductId=UniProtKB:O15169)
9. [Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
10. [Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
11. [The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
12. [I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
13. [Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
14. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
15. [Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
16. [A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
17. [Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
18. [Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
19. [Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
20. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
21. [Axin localizes to the centrosome and is involved in microtubule nucleation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
22. [The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
23. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
24. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
25. [Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
26. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
27. [WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
28. [Kaiso is a bimodal modulator for Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
29. [Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
30. [Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
31. [Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
32. [Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
33. [Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
34. [TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
35. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
36. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
37. [AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
38. [YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
39. [Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
40. [Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
41. [Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
42. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
43. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
44. [Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
45. [Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
46. [The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
47. [RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
48. [The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)
49. [Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15169&geneProductId=UniProtKB:O15169)
50. [Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15169)