Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
positive regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
The autoimmune regulator (AIRE) is a DNA-binding protein
Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)
Modulation of Aire regulates the expression of tissue-restricted antigens
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes