Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, FYVE/PHD-type
additional property: PropertyValue
  property ID: P361
  value: SAND-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, RING/FYVE/PHD-type
additional property: PropertyValue
  property ID: P527
  value: Zinc finger, PHD-type, conserved site
additional property: PropertyValue
  property ID: P527
  value: Zinc finger, PHD-finger
additional property: PropertyValue
  property ID: P527
  value: Zinc finger, PHD-type
additional property: PropertyValue
  property ID: P637
  value: NP_001258478
additional property: PropertyValue
  property ID: P637
  value: NP_001258479
additional property: PropertyValue
  property ID: P637
  value: NP_001258480
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: histone binding
additional property: PropertyValue
  property ID: P680
  value: zinc ion binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: intracellular anatomical structure
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: positive regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P682
  value: humoral immune response
additional property: PropertyValue
  property ID: P702
  value: Aire
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000101034
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000101035
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000114904
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 22
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 22
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9Z0E3
    source count: 1
    confidence: 0.2
  P361:
    value: Q24719950
    source count: 1
    confidence: 0.2
    value label: Zinc finger, FYVE/PHD-type
  P361:
    value: Q24773193
    source count: 1
    confidence: 0.2
    value label: SAND-like domain superfamily
  P361:
    value: Q24786519
    source count: 1
    confidence: 0.2
    value label: Zinc finger, RING/FYVE/PHD-type
  P361:
    value: Q24783415
    source count: 1
    confidence: 0.2
    value label: Autoimmune regulator, AIRE
  P361:
    value: Q83137204
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-finger, protein family
  P527:
    value: Q24775106
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-type, conserved site
  P527:
    value: Q24741217
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-finger
  P527:
    value: Q24778670
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-type
  P527:
    value: Q24727478
    source count: 1
    confidence: 0.2
    value label: HSR domain
  P527:
    value: Q24784234
    source count: 1
    confidence: 0.2
    value label: SAND domain
  P637:
    value: NP_001258478
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001258479
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001258480
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001258481
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001258482
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q14860856
    source count: 4
    confidence: 0.8
    value label: histone binding
  P680:
    value: Q14633865
    source count: 3
    confidence: 0.6
    value label: zinc ion binding
  P680:
    value: Q14817976
    source count: 4
    confidence: 0.8
    value label: chromatin binding
  P680:
    value: Q14864823
    source count: 3
    confidence: 0.6
    value label: RNA polymerase II transcription regulatory region sequence-specific DNA binding

value: Q79899
source count: 3
confidence: 0.6
value label: cytoplasm

value: Q3824358
source count: 1
confidence: 0.2
value label: intracellular anatomical structure

value: Q40260
source count: 4
confidence: 0.8
value label: nucleus

value: Q14817965
source count: 1
confidence: 0.2
value label: nuclear body

value: Q40260
source count: 5
confidence: 1.0
value label: nucleus

value: Q14818066
source count: 3
confidence: 0.6
value label: positive regulation of transcription, DNA-templated

value: Q14633883
source count: 2
confidence: 0.4
value label: regulation of transcription, DNA-templated

value: Q14863386
source count: 2
confidence: 0.4
value label: humoral immune response

value: Q14863717
source count: 1
confidence: 0.2
value label: regulation of translation

value: Q14763010
source count: 1
confidence: 0.2
value label: transcription, DNA-templated

value: Q14907299
source count: 1
confidence: 0.2
value label: Aire

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000101034
source count: 1
confidence: 0.2

value: ENSMUSP00000101035
source count: 1
confidence: 0.2

value: ENSMUSP00000114904
source count: 1
confidence: 0.2

value: ENSMUSP00000115162
source count: 1
confidence: 0.2

value: ENSMUSP00000118317
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: The autoimmune regulator (AIRE) is a DNA-binding protein
stated in qid: Q24291636
retrieved: 2019-02-14

source: Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)
stated in qid: Q28592422
retrieved: 2019-02-14

source: Modulation of Aire regulates the expression of tissue-restricted antigens
stated in qid: Q28509341
retrieved: 2018-09-10

source: Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)
stated in qid: Q28592422
retrieved: 2018-03-27

source: Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
stated in qid: Q28202432
retrieved: 2018-03-27

source: Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
stated in qid: Q28585306
retrieved: 2019-02-14

source: Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
stated in qid: Q28202432
retrieved: 2019-02-14

source: Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
stated in qid: Q28593303
retrieved: 2018-03-27

source: Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells
stated in qid: Q28593219
retrieved: 2018-03-27

source: Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
stated in qid: Q28512316
retrieved: 2018-03-27

source: Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
stated in qid: Q28585306
retrieved: 2018-03-27

source: Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells
stated in qid: Q28593219
retrieved: 2019-02-14

source: Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
stated in qid: Q28512316
retrieved: 2019-02-14

source: Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
stated in qid: Q28593303
retrieved: 2019-02-14

source: Modulation of Aire regulates the expression of tissue-restricted antigens
stated in qid: Q28509341
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14907300
domain: protein
level: standard
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data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-25T15:34:14.532978Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:38:59.049836+00:00Z