# Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

> mammalian protein found in Mus musculus

**Wikidata**: [Q14907300](https://www.wikidata.org/wiki/Q14907300)  
**Source**: https://4ort.xyz/entity/autoimmune-regulator-autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy-


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z0E3)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
7. [The autoimmune regulator (AIRE) is a DNA-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
8. [Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
9. [Modulation of Aire regulates the expression of tissue-restricted antigens](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
10. [Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
11. [Aire deficient mice develop multiple features of APECED phenotype and show altered immune response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
12. [Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
13. [Aire deficient mice develop multiple features of APECED phenotype and show altered immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
14. [Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
15. [Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
16. [Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
17. [Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3)
18. [Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
19. [Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
20. [Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
21. [Modulation of Aire regulates the expression of tissue-restricted antigens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3)
22. ensembl Release 106