# Aurora kinase A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4822488](https://www.wikidata.org/wiki/Q4822488)  
**Source**: https://4ort.xyz/entity/aurora-kinase-a-q4822488


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL483158)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2140408)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL402548)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL482968)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3182444)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL259084)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL482767)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O14965)
11. Q20641742
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
13. [Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
14. [Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
15. [Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
16. [Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
17. [The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
18. [Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
19. [Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
20. [Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
21. [Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
22. [Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
23. [Pitchfork regulates primary cilia disassembly and left-right asymmetry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
24. [Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
25. [Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
26. [Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
27. [SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
28. [N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
29. [Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
30. [A role for IkappaB kinase 2 in bipolar spindle assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
31. [Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
32. [Structural basis of Aurora-A activation by TPX2 at the mitotic spindle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
33. [Drugging MYCN through an allosteric transition in Aurora kinase A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
34. [Protein Phosphorylation Profiling Using an In Situ Proximity Ligation Assay: Phosphorylation of AURKA-Elicited EGFR-Thr654 and EGFR-Ser1046 in Lung Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
35. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
36. [Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
37. [Astrin regulates Aurora-A localization.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
38. [Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
39. [Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
40. [Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
41. [Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
42. [A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
43. [Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
44. [A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
45. [Aurora A, centrosome structure, and the centrosome cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
46. [Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
47. [PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
48. [Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
49. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)
50. [Identification of Ski as a target for Aurora A kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14965)