# ATRX chromatin remodeler

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21105313](https://www.wikidata.org/wiki/Q21105313)  
**Source**: https://4ort.xyz/entity/atrx-chromatin-remodeler-q21105313


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P46100)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
5. [The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
6. [Cloning and characterization of a new human Xq13 gene, encoding a putative helicase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46100&geneProductId=UniProtKB:P46100)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46100&geneProductId=UniProtKB:P46100)
8. [ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
9. [Distinct factors control histone variant H3.3 localization at specific genomic regions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
10. [The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
11. [The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
12. [Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46100&geneProductId=UniProtKB:P46100)
13. [ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
14. [EBV Tegument Protein BNRF1 Disrupts DAXX-ATRX to Activate Viral Early Gene Transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
15. [ATRX directs binding of PRC2 to Xist RNA and Polycomb targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
16. [Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
17. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
18. [ATRX dysfunction induces replication defects in primary mouse cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
19. [Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
20. [Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
21. [The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?protein=P46100&geneProductId=UniProtKB:P46100)
22. [Cloning and characterization of a new human Xq13 gene, encoding a putative helicase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
23. [Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
24. [Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
25. [Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
26. [Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46100)
27. Ensembl Release 99
28. UMLS 2023