# ATR serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4812911](https://www.wikidata.org/wiki/Q4812911)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Ataxia_telangiectasia_and_Rad3_related)  
**Source**: https://4ort.xyz/entity/atr-serine-threonine-kinase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13535)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
6. [cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
7. [MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
8. [ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
9. [Activation of the ATR kinase by the RPA-binding protein ETAA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
10. [CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
11. [ETAA1 acts at stalled replication forks to maintain genome integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
12. [Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
13. [Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
14. [Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
15. [Functional genomic screens identify CINP as a genome maintenance protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
16. [Cyclin‐dependent kinase 9–cyclin K functions in the replication stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
17. [Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
18. [A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
20. [Activation of the ATR kinase by the RPA-binding protein ETAA1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
21. [ETAA1 acts at stalled replication forks to maintain genome integrity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
22. [Activation of the ATM kinase by ionizing radiation and phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
23. [A role for ATR in the DNA damage-induced phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
24. [Activation of the ATM kinase by ionizing radiation and phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
25. [A role for ATR in the DNA damage-induced phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
27. [ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
28. [ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
29. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
30. [MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13535&geneProductId=UniProtKB:Q13535)
31. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
32. [Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
33. [Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13535)
34. Ensembl Release 99