# ATPase cation transporting 13A2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115193](https://www.wikidata.org/wiki/Q21115193)  
**Source**: https://4ort.xyz/entity/atpase-cation-transporting-13a2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NQ11)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
5. [The role of oxidative stress in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
6. [Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
7. [Interaction of divalent cations with peptide fragments from Parkinson's disease genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
8. [A lipid switch unlocks Parkinson's disease-associated ATP13A2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
9. [Mn(II) and Zn(II) interactions with peptide fragments from Parkinson's disease genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11)
11. [Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
12. [PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
13. [Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
14. [Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
15. [ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
16. [ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
17. [ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11)
18. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11)
19. [ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11)
20. [ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
21. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
22. [PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11)
23. [ATP13A2 regulates mitochondrial bioenergetics through macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
24. [Unlocking ATP13A2/PARK9 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
25. [Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
26. [ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
27. [Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
28. [Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
29. [Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
30. [Parkinson's disease-associated human P5B-ATPase ATP13A2 increases spermidine uptake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11)
31. Ensembl Release 99
32. Transporter Classification database