ATP binding cassette subfamily B member 4
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P21439
additional property: PropertyValue
  property ID: P361
  value: ABC transporter type 1, transmembrane domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Multidrug resistance protein 3
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P486
  value: D000097202
additional property: PropertyValue
  property ID: P527
  value: ABC transporter, conserved site
additional property: PropertyValue
  property ID: P527
  value: ABC transporter-like
additional property: PropertyValue
  property ID: P527
  value: ABC transporter type 1, transmembrane domain
additional property: PropertyValue
  property ID: P591
  value: 7.6.2.2
additional property: PropertyValue
  property ID: P637
  value: NP_000434
additional property: PropertyValue
  property ID: P637
  value: NP_061337
additional property: PropertyValue
  property ID: P637
  value: NP_061338
additional property: PropertyValue
  property ID: P672
  value: D09.400.430.890.020.400.767
additional property: PropertyValue
  property ID: P672
  value: D12.776.157.530.100.075.750
additional property: PropertyValue
  property ID: P672
  value: D12.776.157.530.450.074.500.500.250.719
additional property: PropertyValue
  property ID: P680
  value: ATPase-coupled transmembrane transporter activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: ABC-type xenobiotic transporter activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: lipid transport
additional property: PropertyValue
  property ID: P682
  value: cellular response to bile acid
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cholesterol transport
additional property: PropertyValue
  property ID: P692
  value: PBB GE ABCB4 207819 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: ABCB4
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000392983
additional property: PropertyValue
  property ID: P705
  value: ENSP00000265723
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 23
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P21439
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797742
    source count: 1
    confidence: 0.2
    value label: ABC transporter type 1, transmembrane domain superfamily
  P361:
    value: Q41796792
    source count: 1
    confidence: 0.2
    value label: Multidrug resistance protein 3
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q286958
    source count: 1
    confidence: 0.2
    value label: ATP-binding cassette transporter
  P361:
    value: Q4649768
    source count: 1
    confidence: 0.2
    value label: AAA proteins
  P486:
    value: D000097202
    source count: 0
    confidence: 0.0
  P527:
    value: Q24725666
    source count: 1
    confidence: 0.2
    value label: ABC transporter, conserved site
  P527:
    value: Q24772708
    source count: 1
    confidence: 0.2
    value label: ABC transporter-like
  P527:
    value: Q24768525
    source count: 1
    confidence: 0.2
    value label: ABC transporter type 1, transmembrane domain
  P527:
    value: Q24774001
    source count: 1
    confidence: 0.2
    value label: AAA+ ATPase domain
  P591:
    value: 7.6.2.2
    source count: 1
    confidence: 0.2
  P637:
    value: NP_000434
    source count: 1
    confidence: 0.2
  P637:
    value: NP_061337
    source count: 1
    confidence: 0.2
  P637:
    value: NP_061338
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011514610
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011514611
    source count: 1
    confidence: 0.2
  P672:
    value: D09.400.430.890.020.400.767
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.157.530.100.075.750
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.157.530.450.074.500.500.250.719
    source count: 0
    confidence: 0.0

value: D12.776.395.550.020.400.767
source count: 0
confidence: 0.0

value: D12.776.543.550.192.400.767
source count: 0
confidence: 0.0

value: Q14864715
source count: 4
confidence: 0.8
value label: ATPase-coupled transmembrane transporter activity

value: Q14860365
source count: 1
confidence: 0.2
value label: nucleotide binding

value: Q14865099
source count: 1
confidence: 0.2
value label: ABC-type xenobiotic transporter activity

value: Q15330073
source count: 2
confidence: 0.4
value label: phosphatidylcholine transporter activity

value: Q21108023
source count: 3
confidence: 0.6
value label: phosphatidylcholine floppase activity

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14327652
source count: 2
confidence: 0.4
value label: integral component of membrane

value: Q14349455
source count: 3
confidence: 0.6
value label: membrane

value: Q29548
source count: 6
confidence: 1.0
value label: plasma membrane

value: Q14859540
source count: 1
confidence: 0.2
value label: integral component of plasma membrane

value: Q14872727
source count: 1
confidence: 0.2
value label: lipid transport

value: Q21095703
source count: 1
confidence: 0.2
value label: cellular response to bile acid

value: Q21108027
source count: 2
confidence: 0.4
value label: positive regulation of cholesterol transport

value: Q21108026
source count: 1
confidence: 0.2
value label: positive regulation of phospholipid translocation

value: Q14865100
source count: 1
confidence: 0.2
value label: xenobiotic transmembrane transport

value: PBB GE ABCB4 207819 s at fs.png
source count: 0
confidence: 0.0

value: Q15315974
source count: 1
confidence: 0.2
value label: ABCB4

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000392983
source count: 1
confidence: 0.2

value: ENSP00000265723
source count: 1
confidence: 0.2

value: ENSP00000351172
source count: 1
confidence: 0.2

value: ENSP00000352135
source count: 1
confidence: 0.2

value: ENSP00000394511
source count: 1
confidence: 0.2

value: 3.A.1.201.3
source count: 2
confidence: 0.4

source: Phosphatidylcholine translocase: a physiological role for the mdr2 gene
stated in qid: Q24319732
retrieved: 2018-01-01

source: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
stated in qid: Q24317572
retrieved: 2018-01-01

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4
stated in qid: Q24306700
retrieved: 2018-01-01

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Two ABCB4 point mutations of strategic NBD-motifs do not prevent protein targeting to the plasma membrane but promote MDR3 dysfunction
stated in qid: Q24336685
retrieved: 2019-05-09

source: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
stated in qid: Q24317572
retrieved: 2019-05-09

source: Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4
stated in qid: Q24297171
retrieved: 2019-05-09

source: Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4
stated in qid: Q24306700
retrieved: 2019-05-09

source: Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
stated in qid: Q24324106
retrieved: 2019-05-09

source: Phosphatidylcholine translocase: a physiological role for the mdr2 gene
stated in qid: Q24319732
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4
stated in qid: Q24297171
retrieved: 2018-01-01

source: Two ABCB4 point mutations of strategic NBD-motifs do not prevent protein targeting to the plasma membrane but promote MDR3 dysfunction
stated in qid: Q24336685
retrieved: 2018-01-01

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-09-26

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2019-05-09

source: Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
stated in qid: Q24322810
retrieved: 2017-09-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: ENZYME
stated in qid: Q26737758
retrieved: 2019-09-09

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q4650057
domain: protein
level: standard
html url: https://4ort.xyz/entity/atp-binding-cassette-subfamily-b-member-4-q4650057
markdown url: https://4ort.xyz/entity/atp-binding-cassette-subfamily-b-member-4-q4650057.md
facts url summary: https://4ort.xyz/entity/atp-binding-cassette-subfamily-b-member-4-q4650057/facts.json
facts url standard: https://4ort.xyz/entity/atp-binding-cassette-subfamily-b-member-4-q4650057/facts.json
facts url full: https://4ort.xyz/entity/atp-binding-cassette-subfamily-b-member-4-q4650057/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T10:59:58.450207Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:22:02.377504+00:00Z