# ATP binding cassette subfamily A member 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115210](https://www.wikidata.org/wiki/Q21115210)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ABCA1)  
**Source**: https://4ort.xyz/entity/atp-binding-cassette-subfamily-a-member-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL608)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O95477)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
8. [Apolipoprotein specificity for lipid efflux by the human ABCAI transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
9. [ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
10. [Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
11. [Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
12. [Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
13. [Molecular interactions between apoE and ABCA1: impact on apoE lipidation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
14. [Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
15. [HIV-1 Protein Nef Inhibits Activity of ATP-binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
16. [Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
17. [Characterization of the ATPase Cycle of Human ABCA1: Implications for Its Function as a Regulator Rather Than an Active Transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
19. [Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
20. [Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
21. [Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
22. [The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
23. [The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
24. [Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
25. [Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
26. [Apolipoprotein specificity for lipid efflux by the human ABCAI transporter](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
27. [Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477)
28. [Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
29. [Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
30. [Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
31. [MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
32. [The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
33. [Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477)
34. Ensembl Release 99
35. Transporter Classification database
36. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)