# ATM serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q141591](https://www.wikidata.org/wiki/Q141591)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ATM_serine/threonine_kinase)  
**Source**: https://4ort.xyz/entity/atm-serine-threonine-kinase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13315)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
6. [ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
7. [Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315)
9. [USP10 regulates p53 localization and stability by deubiquitinating p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315)
10. [Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315)
11. [NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315)
12. [Activation of the ATM kinase by ionizing radiation and phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13315&geneProductId=UniProtKB:Q13315)
13. [ATM activation by ionizing radiation requires BRCA1-associated BAAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
14. [CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
15. [Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
16. [A role for DEAD box 1 at DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
17. [MDC1 is a mediator of the mammalian DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
18. [Single-stranded DNA-binding protein hSSB1 is critical for genomic stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
19. [Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
20. [Interaction between ATM protein and c-Abl in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
21. [A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
22. [The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
23. [Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
24. [Tel2 regulates the stability of PI3K-related protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
25. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
26. [F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
27. [Systematic identification of molecular links between core and candidate genes in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
28. [Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
29. [Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
30. [The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
31. [Notch is a direct negative regulator of the DNA-damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
32. [ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
33. [ATMIN defines an NBS1-independent pathway of ATM signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
34. [UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
35. [USP10 regulates p53 localization and stability by deubiquitinating p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
36. [NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
37. [Activation of the ATM kinase by ionizing radiation and phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
39. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
40. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
41. [PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
42. [A single ataxia telangiectasia gene with a product similar to PI-3 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
43. [ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
44. [PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
45. [ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
46. [Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
47. [MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
48. [ATM-dependent phosphorylation of ATF2 is required for the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
49. [Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)
50. [A role for ATR in the DNA damage-induced phosphorylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13315)