# ataxin 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21132123](https://www.wikidata.org/wiki/Q21132123)  
**Source**: https://4ort.xyz/entity/ataxin-3-q21132123


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P54252)
3. Q20641742
4. [Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
6. [Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
7. [Co-Chaperone HSJ1a Dually Regulates the Proteasomal Degradation of Ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
8. [An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
9. [Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
10. [Imbalances in p97 co-factor interactions in human proteinopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
11. [An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252)
12. [The role of the central flexible region on the aggregation and conformational properties of human ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252)
14. [A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
15. [Ataxin-3 is a multivalent ligand for the parkin Ubl domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
17. [Ataxin-3 is transported into the nucleus and associates with the nuclear matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
18. [CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252)
19. [CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
20. [Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
21. [Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
22. [Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
23. [Trinucleotide expansion within the MJD1 gene presents clinically as spinocerebellar ataxia and occurs most frequently in German SCA patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54252)
24. [Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P54252&geneProductId=UniProtKB:P54252)
25. Ensembl Release 99
26. UMLS 2023