# Ataxia telangiectasia mutated

> mammalian protein found in Mus musculus

**Wikidata**: [Q14872812](https://www.wikidata.org/wiki/Q14872812)  
**Source**: https://4ort.xyz/entity/ataxia-telangiectasia-mutated


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62388)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
5. [NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
6. [DNA damage-induced activation of p53 by the checkpoint kinase Chk2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
7. [Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
9. [The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
11. [The histone demethylase LSD1/KDM1A promotes the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
12. [Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
13. [NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
14. [p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
15. [Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
16. [Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
17. [Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
18. [Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
19. [Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
20. [PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
21. [ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
22. [Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
23. [Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
24. [PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
25. [Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
26. [Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
27. [Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
28. [BRCA2 is required for neurogenesis and suppression of medulloblastoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
29. [Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
30. [RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
31. [Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
32. [Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
33. [Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
34. [DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62388&geneProductId=UniProtKB:Q62388)
35. [The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
36. [Accumulation of DNA Damage and Reduced Levels of Nicotine Adenine Dinucleotide in the Brains of Atm-deficient Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
37. [Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
38. [DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
39. [Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
40. [BRCA2 is required for neurogenesis and suppression of medulloblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
41. [The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62388)
42. ensembl Release 106