# Arrestin beta 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109248](https://www.wikidata.org/wiki/Q21109248)  
**Source**: https://4ort.xyz/entity/arrestin-beta-2-q21109248


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P32121)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
5. [Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
6. [Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
7. [Novel function of beta-arrestin2 in the nucleus of mature spermatozoa](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
8. [The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
9. [Ubiquitination of CXCR7 controls receptor trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
10. [Carboxy-terminus of CXCR7 regulates receptor localization and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
11. [Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
12. [β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
13. [Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
14. [Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
15. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
16. [A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
17. [β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
18. [Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
19. [A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
20. [Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
22. [Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
23. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
24. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
25. [Distinct roles for β‐arrestin2 and arrestin‐domain‐containing proteins in β2 adrenergic receptor trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
26. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
27. [An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
28. [Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
29. [Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
30. [A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
31. [beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
32. [An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
33. [beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
34. [{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
36. [A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
37. [G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
38. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P32121&geneProductId=UniProtKB:P32121)
39. [A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
40. [Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
41. [Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121)
42. Ensembl Release 99
43. UMLS 2023