ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: small GTPase
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P361
  value: PH-like domain superfamily
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat
additional property: PropertyValue
  property ID: P527
  value: pleckstrin homology domain
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat-containing domain
additional property: PropertyValue
  property ID: P637
  value: NP_075415
additional property: PropertyValue
  property ID: P637
  value: XP_006241561
additional property: PropertyValue
  property ID: P637
  value: XP_006241562
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: GTPase activity
additional property: PropertyValue
  property ID: P680
  value: GTPase activator activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleolus
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: positive regulation of phosphatidylinositol 3-kinase signaling
additional property: PropertyValue
  property ID: P682
  value: activation of protein kinase activity
additional property: PropertyValue
  property ID: P682
  value: positive regulation of mammary gland epithelial cell proliferation
additional property: PropertyValue
  property ID: P702
  value: Agap2
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000029533
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000069597
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000093674
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 10
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 10
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q8CGU4
    source count: 1
    confidence: 0.2
  P361:
    value: Q24781762
    source count: 1
    confidence: 0.2
    value label: small GTPase
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q24786013
    source count: 1
    confidence: 0.2
    value label: PH-like domain superfamily
  P361:
    value: Q41798353
    source count: 1
    confidence: 0.2
    value label: ARFGAP/RecO-like zinc finger
  P361:
    value: Q41797869
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat-containing domain superfamily
  P527:
    value: Q24784174
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat
  P527:
    value: Q24776397
    source count: 1
    confidence: 0.2
    value label: pleckstrin homology domain
  P527:
    value: Q24778891
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat-containing domain
  P527:
    value: Q24766985
    source count: 1
    confidence: 0.2
    value label: Arf GTPase activating protein
  P637:
    value: NP_075415
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006241561
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006241562
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038935796
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038935797
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14865041
    source count: 1
    confidence: 0.2
    value label: GTPase activity
  P680:
    value: Q14908102
    source count: 2
    confidence: 0.4
    value label: GTPase activator activity
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P680:
    value: Q14863341
    source count: 2
    confidence: 0.4
    value label: GTP binding
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus

value: Q30869
source count: 1
confidence: 0.2
value label: nucleolus

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q39572
source count: 1
confidence: 0.2
value label: mitochondrion

value: Q220599
source count: 1
confidence: 0.2
value label: cytosol

value: Q14330982
source count: 2
confidence: 0.4
value label: positive regulation of phosphatidylinositol 3-kinase signaling

value: Q14860509
source count: 1
confidence: 0.2
value label: activation of protein kinase activity

value: Q15311857
source count: 1
confidence: 0.2
value label: positive regulation of mammary gland epithelial cell proliferation

value: Q14599533
source count: 1
confidence: 0.2
value label: negative regulation of apoptotic process

value: Q14820618
source count: 2
confidence: 0.4
value label: negative regulation of neuron apoptotic process

value: Q24396856
source count: 1
confidence: 0.2
value label: Agap2

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000029533
source count: 1
confidence: 0.2

value: ENSRNOP00000069597
source count: 1
confidence: 0.2

value: ENSRNOP00000093674
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression
stated in qid: Q28511024
retrieved: 2019-02-14

source: Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
stated in qid: Q24311684
retrieved: 2019-02-14

source: PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
stated in qid: Q28207557
retrieved: 2019-02-14

source: Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
stated in qid: Q24290689
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q28557301
domain: protein
level: standard
html url: https://4ort.xyz/entity/arfgap-with-gtpase-domain-ankyrin-repeat-and-ph-domain-2-q28557301
markdown url: https://4ort.xyz/entity/arfgap-with-gtpase-domain-ankyrin-repeat-and-ph-domain-2-q28557301.md
facts url summary: https://4ort.xyz/entity/arfgap-with-gtpase-domain-ankyrin-repeat-and-ph-domain-2-q28557301/facts.json
facts url standard: https://4ort.xyz/entity/arfgap-with-gtpase-domain-ankyrin-repeat-and-ph-domain-2-q28557301/facts.json
facts url full: https://4ort.xyz/entity/arfgap-with-gtpase-domain-ankyrin-repeat-and-ph-domain-2-q28557301/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T06:32:06.824438Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:13:18.529887+00:00Z