# Aprataxin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q15996558](https://www.wikidata.org/wiki/Q15996558)  
**Source**: https://4ort.xyz/entity/aprataxin-q15996558


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q7Z2E3)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
5. [Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
6. [Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
7. [Aprataxin, a novel protein that protects against genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
8. [Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
9. [CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
10. [XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
11. [A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
12. [The FHA domain of aprataxin interacts with the C-terminal region of XRCC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
14. [The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
15. [Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
16. [Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
17. [Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
18. [Actions of aprataxin in multiple DNA repair pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
20. [Actions of aprataxin in multiple DNA repair pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
21. [The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
23. [The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7Z2E3)
24. [Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7Z2E3&geneProductId=UniProtKB:Q7Z2E3)
25. Ensembl Release 99