# Apoptotic peptidase activating factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109162](https://www.wikidata.org/wiki/Q21109162)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/APAF1)  
**Source**: https://4ort.xyz/entity/apoptotic-peptidase-activating-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O14727)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
5. [Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
6. [Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
7. [Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
8. [CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
9. [A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
10. [Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
11. [Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
12. [An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
13. [Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
14. [The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
15. [The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
16. [Structure of an apoptosome-procaspase-9 CARD complex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
17. [p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
18. [A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
19. [A soluble version of the receptor-like protein tyrosine phosphatase kappa stimulates neurite outgrowth via a Grb2/MEK1-dependent signaling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
20. [Analysis of APAF-1 expression in human cutaneous melanoma progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
23. [Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
24. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
25. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
26. [The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
27. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
28. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
29. [Three new types of Apaf-1 in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
30. [Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14727)
31. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14727&geneProductId=UniProtKB:O14727)
32. Ensembl Release 99