# Apolipoprotein E

> mammalian protein found in Mus musculus

**Wikidata**: [Q21416505](https://www.wikidata.org/wiki/Q21416505)  
**Source**: https://4ort.xyz/entity/apolipoprotein-e-q21416505


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08226)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
7. [Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
8. [Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
9. [Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
10. [RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08226&geneProductId=UniProtKB:P08226)
12. [Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
13. [Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
14. [Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
15. [Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
16. [ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
17. [Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
18. [Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
19. [Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
20. [Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
21. [Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
22. [Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
23. [Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
24. [Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
25. [Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
26. [IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
27. [Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
28. [Delayed arteriogenesis in hypercholesterolemic mice](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
29. [Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
30. [Increased 3-nitrotyrosine in brains of Apo E-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
31. [Delayed arteriogenesis in hypercholesterolemic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
32. [Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
33. [Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
34. [Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
35. [Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
36. [Apolipoprotein E and Apolipoprotein A-1 Knock-Out Mice Readily Develop Amyloid A Protein Amyloidosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
37. [Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
38. [Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
39. [Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
40. [IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
41. [Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
42. [Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08226)
43. [Effects of apo E Deficiency on Plasma Lipid Levels in Mice Lacking APOBEC-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
44. [Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
45. [Isoform-specific effects of ApoE on neurite outgrowth in Olfactory Epithelium culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
46. [Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
47. [Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
48. [Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
49. [Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)
50. [LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08226)