# APC regulator of WNT signaling pathway

> mammalian protein found in Homo sapiens

**Wikidata**: [Q356062](https://www.wikidata.org/wiki/Q356062)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Apc,_wnt_signaling_pathway_regulator)  
**Source**: https://4ort.xyz/entity/apc-regulator-of-wnt-signaling-pathway


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P25054)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054)
6. [Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
7. [An EB1-binding motif acts as a microtubule tip localization signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
9. [The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
10. [Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
11. [The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
12. [Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
13. [Asef, a link between the tumor suppressor APC and G-protein signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
14. [Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
15. [Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
16. [The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
17. [Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
18. [Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
19. [Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
20. [Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
21. [Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
22. [The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
23. [AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
24. [Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
25. [A role for the Adenomatous Polyposis Coli protein in chromosome segregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
26. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
27. [Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
28. [Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
29. [Proteome-wide analysis of phospho-regulated PDZ domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
30. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
31. [Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
32. [Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
33. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
34. [Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
35. [A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
36. [Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
37. [Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
38. [Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
39. [Modeling of a human circadian mutation yields insights into clock regulation by PER2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
40. [Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC‐binding proteins, is a positive regulator of Wnt–β‐catenin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
41. [Rho GTPase Cdc42 Is a Direct Interacting Partner of Adenomatous Polyposis Coli Protein and Can Alter Its Cellular Localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
42. [Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
43. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
44. [Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
45. [Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
46. [Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25054)
47. [Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054)
48. [Regulation and function of the interaction between the APC tumour suppressor protein and EB1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054)
49. [The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054)
50. [A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals](http://www.ebi.ac.uk/QuickGO/annotations?protein=P25054&geneProductId=UniProtKB:P25054)