# angiotensin I converting enzyme

> mammalian protein found in Homo sapiens

**Wikidata**: [Q128861](https://www.wikidata.org/wiki/Q128861)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme)  
**Source**: https://4ort.xyz/entity/angiotensin-i-converting-enzyme


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL317094)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL589583)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1165)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1694)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200659)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200343)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201011)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12821)
11. Q20641742
12. Freebase Data Dumps. 2013
13. [Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
14. [Crystal structure of the human angiotensin-converting enzyme-lisinopril complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
15. [Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
16. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
17. [Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
19. [Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
20. [Human ACE and bradykinin B2 receptors form a complex at the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
21. [Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
22. [Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
23. [Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
24. [The two homologous domains of human angiotensin I-converting enzyme are both catalytically active](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
25. [Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
26. [Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
28. [Human ACE and bradykinin B2 receptors form a complex at the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
29. [Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
30. [Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
31. [The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
32. [RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
33. [The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
34. [The two homologous domains of human angiotensin I-converting enzyme are both catalytically active](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
35. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
36. [Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
37. [Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
38. [Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)
39. [Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
40. [The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
41. [Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in chinese hamster ovary cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
42. [Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
43. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
44. [RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
45. [Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
46. [Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
47. [Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
48. [The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
49. [Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12821)
50. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12821&geneProductId=UniProtKB:P12821)