# angiotensin I converting enzyme 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q301630](https://www.wikidata.org/wiki/Q301630)  
**Source**: https://4ort.xyz/entity/angiotensin-i-converting-enzyme-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9BYF1)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
6. [TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
8. [Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
9. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
10. [Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
11. [A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
13. [A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
14. [Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
15. [A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
16. [Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
17. [Cloning and characterization of a secreted form of angiotensin-converting enzyme 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
18. [Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
19. [A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
20. [Cloning and characterization of a secreted form of angiotensin-converting enzyme 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
21. [Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
23. [A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
24. [Lipid rafts are involved in SARS-CoV entry into Vero E6 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
25. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
26. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1)
27. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
28. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
29. [Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
30. [ACE2: a new target for cardiovascular disease therapeutics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
31. [ACE2: from vasopeptidase to SARS virus receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1)
32. Ensembl Release 99
33. Identifiers.org
34. UMLS 2023
35. [Source](https://www.guidetopharmacology.org/coronavirus.jsp)
36. Transporter Classification database