# Amyloid beta precursor protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q423510](https://www.wikidata.org/wiki/Q423510)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Amyloid-beta_precursor_protein)  
**Source**: https://4ort.xyz/entity/amyloid-beta-precursor-protein


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3039540)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05067)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
7. [CD74 interacts with APP and suppresses the production of Abeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
8. [beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05067)
9. [FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
10. [BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
11. [Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
12. [RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
13. [Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
14. [Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
15. [Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
16. [Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
17. [Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
18. [APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
19. [Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
20. [X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
21. [APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
22. [Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
23. [beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
24. [beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
25. [Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
26. [The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
27. [Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's β-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
28. [Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
29. [A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
30. [Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
31. [Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
32. [Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
33. [sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
34. [Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
35. [In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
36. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
37. [APP binds DR6 to trigger axon pruning and neuron death via distinct caspases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
38. [Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
39. [Mediator is a transducer of amyloid‐precursor‐protein‐dependent nuclear signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
40. [Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
41. [Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
42. [Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
43. [The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
44. [Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
45. [Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
46. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
47. [Impact of the Cellular Prion Protein on Amyloid-β and 3PO-Tau Processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
48. [An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
49. [Interactome mapping suggests new mechanistic details underlying Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)
50. [Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05067)