# Amyloid beta (A4) precursor protein

> mammalian protein found in Mus musculus

**Wikidata**: [Q14865884](https://www.wikidata.org/wiki/Q14865884)  
**Source**: https://4ort.xyz/entity/amyloid-beta-a4-precursor-protein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P12023)
3. Q20641742
4. [Megalin interacts with APP and the intracellular adapter protein FE65 in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
5. [Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
6. [Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
7. [Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting ProteinIn VivoThat Modulates Amyloidogenic ProcessingIn Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
8. [Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
9. [VPS35 regulates cell surface recycling and signaling of dopamine receptor D1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
10. [Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
11. [Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
12. [F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
13. [LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
14. [A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
15. [The in vivo brain interactome of the amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
16. [Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
17. [Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
18. [c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
19. [Homo- and heterodimerization of APP family members promotes intercellular adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
20. [Crystal structures of the Dab homology domains of mouse disabled 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
21. [Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
22. [Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
23. [Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
24. [Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
25. [Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
26. [Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
28. [Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
29. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P12023)
30. [Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
31. [Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
32. [The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
33. [Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
34. [Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12023&geneProductId=UniProtKB:P12023)
35. [Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12023&geneProductId=UniProtKB:P12023)
36. [The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
37. [Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
38. [Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
39. [Spatial segregation of gamma-secretase and substrates in distinct membrane domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
40. [Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
41. [Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
42. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12023&geneProductId=UniProtKB:P12023)
43. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
44. [Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
45. [Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P12023&geneProductId=UniProtKB:P12023)
46. [An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
47. [Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
48. [TREM2 regulates microglial cell activation in response to demyelination in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
49. [Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)
50. [Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12023)