Aminomethyltransferase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P48728
additional property: PropertyValue
  property ID: P361
  value: Glycine cleavage T-protein/YgfZ, C-terminal
additional property: PropertyValue
  property ID: P361
  value: Glycine cleavage system T protein
additional property: PropertyValue
  property ID: P361
  value: GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
additional property: PropertyValue
  property ID: P486
  value: D050960
additional property: PropertyValue
  property ID: P527
  value: Aminomethyltransferase, folate-binding domain
additional property: PropertyValue
  property ID: P527
  value: Glycine cleavage T-protein, C-terminal barrel domain
additional property: PropertyValue
  property ID: P637
  value: NP_000472
additional property: PropertyValue
  property ID: P637
  value: NP_001158182
additional property: PropertyValue
  property ID: P637
  value: NP_001158183
additional property: PropertyValue
  property ID: P638
  value: 1WSR
additional property: PropertyValue
  property ID: P638
  value: 1WSV
additional property: PropertyValue
  property ID: P672
  value: D05.500.562.452.100
additional property: PropertyValue
  property ID: P672
  value: D08.811.600.391.100
additional property: PropertyValue
  property ID: P672
  value: D08.811.913.555.400.100
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: transaminase activity
additional property: PropertyValue
  property ID: P680
  value: aminomethyltransferase activity
additional property: PropertyValue
  property ID: P681
  value: mitochondrial matrix
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P682
  value: methylation
additional property: PropertyValue
  property ID: P682
  value: glycine catabolic process
additional property: PropertyValue
  property ID: P682
  value: glycine decarboxylation via glycine cleavage system
additional property: PropertyValue
  property ID: P702
  value: AMT
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000273588
additional property: PropertyValue
  property ID: P705
  value: ENSP00000378747
additional property: PropertyValue
  property ID: P705
  value: ENSP00000415619
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 13
      unique citations norm: 0.005
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 13
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P48728
    source count: 1
    confidence: 0.2
  P361:
    value: Q24770690
    source count: 1
    confidence: 0.2
    value label: Glycine cleavage T-protein/YgfZ, C-terminal
  P361:
    value: Q24769874
    source count: 1
    confidence: 0.2
    value label: Glycine cleavage system T protein
  P361:
    value: Q54456704
    source count: 1
    confidence: 0.2
    value label: GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
  P361:
    value: Q83138858
    source count: 1
    confidence: 0.2
    value label: Aminomethyltransferase, folate-binding domain, protein family
  P361:
    value: Q83140117
    source count: 1
    confidence: 0.2
    value label: Glycine cleavage T-protein, C-terminal barrel domain, protein family
  P486:
    value: D050960
    source count: 0
    confidence: 0.0
  P527:
    value: Q24769505
    source count: 1
    confidence: 0.2
    value label: Aminomethyltransferase, folate-binding domain
  P527:
    value: Q24771044
    source count: 1
    confidence: 0.2
    value label: Glycine cleavage T-protein, C-terminal barrel domain
  P637:
    value: NP_000472
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158182
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158183
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001158184
    source count: 1
    confidence: 0.2
  P638:
    value: 1WSR
    source count: 1
    confidence: 0.2
  P638:
    value: 1WSV
    source count: 1
    confidence: 0.2
  P672:
    value: D05.500.562.452.100
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.600.391.100
    source count: 0
    confidence: 0.0
  P672:
    value: D08.811.913.555.400.100
    source count: 0
    confidence: 0.0
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14903610
    source count: 1
    confidence: 0.2
    value label: transaminase activity

value: Q21110354
source count: 4
confidence: 0.8
value label: aminomethyltransferase activity

value: Q21110354
source count: 5
confidence: 1.0
value label: aminomethyltransferase activity

value: Q3493378
source count: 1
confidence: 0.2
value label: mitochondrial matrix

value: Q14817956
source count: 1
confidence: 0.2
value label: nucleoplasm

value: Q39572
source count: 4
confidence: 0.8
value label: mitochondrion

value: Q39572
source count: 5
confidence: 1.0
value label: mitochondrion

value: Q518328
source count: 1
confidence: 0.2
value label: methylation

value: Q21110355
source count: 2
confidence: 0.4
value label: glycine catabolic process

value: Q21115951
source count: 1
confidence: 0.2
value label: glycine decarboxylation via glycine cleavage system

value: Q21115951
source count: 2
confidence: 0.4
value label: glycine decarboxylation via glycine cleavage system

value: Q1632039
source count: 1
confidence: 0.2
value label: AMT

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000273588
source count: 1
confidence: 0.2

value: ENSP00000378747
source count: 1
confidence: 0.2

value: ENSP00000415619
source count: 1
confidence: 0.2

value: ENSP00000443200
source count: 1
confidence: 0.2

value: ENSP00000388068
source count: 1
confidence: 0.2

value: C0103013
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia
stated in qid: Q28115081
retrieved: 2018-03-27

source: Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia
stated in qid: Q28115081
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Structure and chromosomal localization of the aminomethyltransferase gene (AMT)
stated in qid: Q24314676
retrieved: 2018-03-27

source: Structure and chromosomal localization of the aminomethyltransferase gene (AMT)
stated in qid: Q24314676
retrieved: 2019-04-08

source: A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia
stated in qid: Q28114847
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-25

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21110356
domain: protein
level: standard
html url: https://4ort.xyz/entity/aminomethyltransferase
markdown url: https://4ort.xyz/entity/aminomethyltransferase.md
facts url summary: https://4ort.xyz/entity/aminomethyltransferase/facts.json
facts url standard: https://4ort.xyz/entity/aminomethyltransferase/facts.json
facts url full: https://4ort.xyz/entity/aminomethyltransferase/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T04:40:44.271285Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z