# Alsin Rho guanine nucleotide exchange factor

> mammalian protein found in Mus musculus

**Wikidata**: [Q21982984](https://www.wikidata.org/wiki/Q21982984)  
**Source**: https://4ort.xyz/entity/alsin-rho-guanine-nucleotide-exchange-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q920R0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
5. [Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
6. [Alsin is partially associated with centrosome in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
7. [Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
8. [Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
9. [Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
10. [Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920R0)
11. ensembl Release 106