# Alsin Rho guanine nucleotide exchange factor ALS2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173260](https://www.wikidata.org/wiki/Q21173260)  
**Source**: https://4ort.xyz/entity/alsin-rho-guanine-nucleotide-exchange-factor-als2-q21173260


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96Q42)
3. Q20641742
4. [Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
6. [ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
7. [Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
8. [ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
9. [Alsin is partially associated with centrosome in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
10. [A novel somatodendritic marker defined by a peptide derived from the ALS2 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
11. [ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q42)
12. Ensembl Release 99