Alpha-2-macroglobulin
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P06238
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Alpha-macroglobulin, receptor-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin E-set
additional property: PropertyValue
  property ID: P527
  value: Alpha-macroglobulin, receptor-binding
additional property: PropertyValue
  property ID: P527
  value: Alpha-2-macroglobulin, bait region domain
additional property: PropertyValue
  property ID: P527
  value: Alpha-2-macroglobulin
additional property: PropertyValue
  property ID: P637
  value: NP_036620
additional property: PropertyValue
  property ID: P637
  value: XP_038962922
additional property: PropertyValue
  property ID: P637
  value: XP_038962923
additional property: PropertyValue
  property ID: P680
  value: endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P680
  value: serine-type endopeptidase inhibitor activity
additional property: PropertyValue
  property ID: P680
  value: peptidase inhibitor activity
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P682
  value: luteinization
additional property: PropertyValue
  property ID: P682
  value: acute inflammatory response to antigenic stimulus
additional property: PropertyValue
  property ID: P682
  value: acute-phase response
additional property: PropertyValue
  property ID: P702
  value: LOC100911545
additional property: PropertyValue
  property ID: P702
  value: A2m
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000019346
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000066130
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 17
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 17
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P06238
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q41797697
    source count: 1
    confidence: 0.2
    value label: Alpha-macroglobulin, receptor-binding domain superfamily
  P361:
    value: Q24780081
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin E-set
  P361:
    value: Q24778163
    source count: 1
    confidence: 0.2
    value label: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
  P361:
    value: Q83138770
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, protein family
  P527:
    value: Q24725003
    source count: 1
    confidence: 0.2
    value label: Alpha-macroglobulin, receptor-binding
  P527:
    value: Q24770317
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, bait region domain
  P527:
    value: Q24769303
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin
  P527:
    value: Q24777118
    source count: 1
    confidence: 0.2
    value label: Macroglobulin domain
  P527:
    value: Q24772656
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, conserved site
  P637:
    value: NP_036620
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038962922
    source count: 1
    confidence: 0.2
  P637:
    value: XP_038962923
    source count: 1
    confidence: 0.2
  P680:
    value: Q14861841
    source count: 2
    confidence: 0.4
    value label: endopeptidase inhibitor activity
  P680:
    value: Q14859581
    source count: 1
    confidence: 0.2
    value label: serine-type endopeptidase inhibitor activity
  P680:
    value: Q14861063
    source count: 1
    confidence: 0.2
    value label: peptidase inhibitor activity
  P680:
    value: Q14762996
    source count: 1
    confidence: 0.2
    value label: protein homodimerization activity
  P680:
    value: Q14897696
    source count: 1
    confidence: 0.2
    value label: brain-derived neurotrophic factor binding
  P681:
    value: Q14645596
    source count: 2
    confidence: 0.4
    value label: extracellular region

value: Q1385443
source count: 2
confidence: 0.4
value label: extracellular space

value: Q1385443
source count: 3
confidence: 0.6
value label: extracellular space

value: Q15312522
source count: 1
confidence: 0.2
value label: luteinization

value: Q14905642
source count: 1
confidence: 0.2
value label: acute inflammatory response to antigenic stimulus

value: Q14758908
source count: 2
confidence: 0.4
value label: acute-phase response

value: Q14860808
source count: 1
confidence: 0.2
value label: response to nutrient

value: Q14819463
source count: 1
confidence: 0.2
value label: response to wounding

value: Q24415595
source count: 1
confidence: 0.2
value label: LOC100911545

value: Q24420994
source count: 1
confidence: 0.2
value label: A2m

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000019346
source count: 1
confidence: 0.2

value: ENSRNOP00000066130
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Role of nitric oxide in the regulation of activity of proteinase inhibitors alpha(1)-antitrypsin and alpha(2)-macroglobulin by capsaicin-sensitive nerves
stated in qid: Q28574391
retrieved: 2019-02-14

source: Purification and properties of rat α2 acute-phase macroglobulin
stated in qid: Q28573402
retrieved: 2019-05-09

source: Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins
stated in qid: Q28565985
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Alpha 2-macroglobulin synthesis in an astrocyte subpopulation
stated in qid: Q28582293
retrieved: 2019-02-14

source: Hormonal regulation and tissue-specific localization of alpha 2-macroglobulin in rat ovarian follicles and corpora lutea
stated in qid: Q28568134
retrieved: 2019-05-09

source: Role of prostaglandins in acute phase proteins in inflammation
stated in qid: Q28566341
retrieved: 2019-05-09

source: Structure and acute-phase regulation of the rat alpha 2-macroglobulin gene
stated in qid: Q28582952
retrieved: 2019-05-09

source: Induction and Modulation of Acute-Phase Response by Protein Malnutrition in Rats: Comparative Effect of Systemic and Localized Inflammation on Interleukin-6 and Acute-Phase Protein Synthesis ,
stated in qid: Q28580754
retrieved: 2019-05-09

source: Carbon dioxide pneumoperitoneum alters acute-phase response induced by lipopolysaccharide
stated in qid: Q28573561
retrieved: 2019-05-09

source: Kupffer cell stimulation of alpha 2-macroglobulin synthesis in rat hepatocytes and the role of glucocorticoid
stated in qid: Q28569603
retrieved: 2019-05-09

source: The development of rat alpha 2-macroglobulin. Studies in vivo and in cultured fetal rat hepatocytes
stated in qid: Q28577854
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q28556038
domain: protein
level: standard
html url: https://4ort.xyz/entity/alpha-2-macroglobulin-q28556038
markdown url: https://4ort.xyz/entity/alpha-2-macroglobulin-q28556038.md
facts url summary: https://4ort.xyz/entity/alpha-2-macroglobulin-q28556038/facts.json
facts url standard: https://4ort.xyz/entity/alpha-2-macroglobulin-q28556038/facts.json
facts url full: https://4ort.xyz/entity/alpha-2-macroglobulin-q28556038/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T18:26:19.789066Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:58:40.809833+00:00Z