Alpha-2-macroglobulin
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Alpha-macroglobulin, receptor-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin E-set
additional property: PropertyValue
  property ID: P527
  value: Alpha-2-macroglobulin, bait region domain
additional property: PropertyValue
  property ID: P527
  value: Alpha-macroglobulin, TED domain
additional property: PropertyValue
  property ID: P527
  value: Macroglobulin domain
additional property: PropertyValue
  property ID: P637
  value: NP_783327
additional property: PropertyValue
  property ID: P637
  value: XP_011239624
additional property: PropertyValue
  property ID: P680
  value: peptidase inhibitor activity
additional property: PropertyValue
  property ID: P680
  value: interleukin-8 binding
additional property: PropertyValue
  property ID: P680
  value: growth factor binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P682
  value: negative regulation of peptidase activity
additional property: PropertyValue
  property ID: P682
  value: female pregnancy
additional property: PropertyValue
  property ID: P682
  value: stem cell differentiation
additional property: PropertyValue
  property ID: P702
  value: A2m
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000032203
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000144862
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 9
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 9
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q6GQT1
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q41797697
    source count: 1
    confidence: 0.2
    value label: Alpha-macroglobulin, receptor-binding domain superfamily
  P361:
    value: Q24780081
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin E-set
  P361:
    value: Q24778163
    source count: 1
    confidence: 0.2
    value label: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
  P361:
    value: Q83138770
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, protein family
  P527:
    value: Q24770317
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, bait region domain
  P527:
    value: Q24770123
    source count: 1
    confidence: 0.2
    value label: Alpha-macroglobulin, TED domain
  P527:
    value: Q24777118
    source count: 1
    confidence: 0.2
    value label: Macroglobulin domain
  P527:
    value: Q24769303
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin
  P527:
    value: Q24772656
    source count: 1
    confidence: 0.2
    value label: Alpha-2-macroglobulin, conserved site
  P637:
    value: NP_783327
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011239624
    source count: 1
    confidence: 0.2
  P680:
    value: Q14861063
    source count: 2
    confidence: 0.4
    value label: peptidase inhibitor activity
  P680:
    value: Q21113123
    source count: 2
    confidence: 0.4
    value label: interleukin-8 binding
  P680:
    value: Q14877469
    source count: 2
    confidence: 0.4
    value label: growth factor binding
  P680:
    value: Q14881068
    source count: 2
    confidence: 0.4
    value label: calcium-dependent protein binding
  P680:
    value: Q14758894
    source count: 2
    confidence: 0.4
    value label: protease binding
  P681:
    value: Q14645596
    source count: 2
    confidence: 0.4
    value label: extracellular region
  P681:
    value: Q1385443
    source count: 2
    confidence: 0.4
    value label: extracellular space
  P681:
    value: Q1385443
    source count: 3
    confidence: 0.6
    value label: extracellular space

value: Q14861064
source count: 1
confidence: 0.2
value label: negative regulation of peptidase activity

value: Q14819850
source count: 1
confidence: 0.2
value label: female pregnancy

value: Q14864672
source count: 1
confidence: 0.2
value label: stem cell differentiation

value: Q14865076
source count: 2
confidence: 0.4
value label: negative regulation of complement activation, lectin pathway

value: Q14859614
source count: 1
confidence: 0.2
value label: negative regulation of endopeptidase activity

value: Q18298079
source count: 1
confidence: 0.2
value label: A2m

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000032203
source count: 1
confidence: 0.2

value: ENSMUSP00000144862
source count: 1
confidence: 0.2

source: The primary sequence and the subunit structure of mouse α‐2‐macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA
stated in qid: Q28587803
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
stated in qid: Q24672149
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
stated in qid: Q28506983
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21431256
domain: protein
level: standard
html url: https://4ort.xyz/entity/alpha-2-macroglobulin-q21431256
markdown url: https://4ort.xyz/entity/alpha-2-macroglobulin-q21431256.md
facts url summary: https://4ort.xyz/entity/alpha-2-macroglobulin-q21431256/facts.json
facts url standard: https://4ort.xyz/entity/alpha-2-macroglobulin-q21431256/facts.json
facts url full: https://4ort.xyz/entity/alpha-2-macroglobulin-q21431256/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T18:26:18.957281Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:25:28.428708+00:00Z